Amine was born in Casablanca, Morocco. He migrated to Canada with this family at the age of 4. He received his Medical Degree and a Master’s of Science from the University of Montreal. After medical school, he joined the Cardiac Surgery Residency program at the University of Toronto, where his clinical interest crystallized around congenital heart disease and complex valve surgery. Amine also has a keen interest in the global burden of heart disease in the developing world, and takes part in yearly surgical missions to countries such as Egypt and Ethiopia.

Amine is currently a PhD candidate in Biomedical Engineering in the University of Toronto’s Institute of Biomaterials & Biomedical Engineering. His research focuses on the generation of the cardiac valve lineage from human embryonic stem cells, and on the generation of human pluripotent stem cell-derived left ventricular cardiomyocytes for the treatment of hypoplastic left heart syndrome.

He is an avid traveler and has visited over 30 countries. His extra-curricular interests include scuba diving, history, language learning, martial arts, and board games.


    • Congenital Heart Disease
    • Neonatal and Infant Surgery
    • Surgery for Adults with Congenital Heart Defects
    • Valve Surgery for Children and Young Adults
    • Surgery for Rheumatic Heart Disease

    • PhD Candidate — University of Toronto (2018 - Present)
    • Cardiac Surgery Residency — University of Toronto (2015 - Present)
    • Master’s Degree — University of Montreal (2012 - 2014) — MSc
    • Medical Degree — University of Montreal (2010 - 2015) — MD

    2020 – PSI Foundation Research Trainee Award
    2019 – CSCI/CIHR Resident Research Award
    2019 – Joseph M. West Family Memorial Fund
    2019 – Edward Christie Stevens Fellowships in Medicine
    2019 – Edie Steinberg Scholarship Fund
    2019 – Dr. Charles Kerr Award
    2019 – CIHR Fellowship Award
    2019 – Vanier Canadian Graduate Scholarship [declined]
    2019 – Thoracic Surgery Foundation (TSF) Resident Research Fellowship Award
    2018 – Peter Munk Research Scholarship
    2018 – Canadian Society of Cardiac Surgeons Resident Research Award
    2017 – Canadian Cardiovascular Society-Bayer Resident Vascular Awards Finalist
    2016 – Annual Cardiology Conference Rockies Resident Research Competition Winner
    2016 – MACK Foundation Postgraduate Trainee Bursary
    2016 – Canadian Cardiovascular Society Trainee Research Award Finalist
    2016 – ACC Rockies Resident Research Competition Winner



    Full publication list available on PubMed:


    Mazine A, El-Hamamsy I, Verma S, Peterson MD, Bonow RO, Yacoub MH, David TE, Bhatt DL. Ross Procedure in Adults for Cardiologists and Cardiac Surgeons: JACC State-of-the-Art Review. J Am Coll Cardiol 2018;72:2761-77.

    Mazine A, David TE, Rao V, Hickey EJ, Christie S, Manlhiot C, Ouzounian M. Long-Term Outcomes of the Ross Procedure Versus Mechanical Aortic Valve Replacement: Propensity-Matched Cohort Study. Circulation 2016;134:576-85.

    Mazine A, Rocha RV, El-Hamamsy I, Ouzounian M, Yanagawa B, Bhatt DL, Verma S, Friedrich JO. Ross Procedure vs Mechanical Aortic Valve Replacement in Adults: A Systematic Review and Meta-analysis. JAMA Cardiol 2018;3:978-87.

    Mazine A, Stevens LM, Ghoneim A, Chung J, Ouzounian M, Dagenais F, El-Hamamsy I, Boodhwani M, Bozinovski J, Peterson MD, Chu MWA; Canadian Thoracic Aortic Collaborative Investigators. Developing Skills for Thoracic Aortic Surgery with Hypothermic Circulatory Arrest. J Thorac Cardiovasc Surg 2018;157:1360-8.

    Mikryukov AA, Mazine A, Wei B, Yang D, Miao Y, Gu M, Keller GM. BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors. Cell Stem Cell 2020. doi: 10.1016/j.stem.2020.10.003. [Online ahead of print]


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